Sustainable water resources management involves social, economic, environmental, water use, and resources factors. This study proposes a new framework of strategic planning with multi-criteria decision-making to develop sustainable water management alternatives for large scale water resources systems. A fuzzy multi-criteria decision-making model is developed to rank regional management alternatives for agricultural water management considering water-resources sustainability criteria. The decision-making model combines hierarchical analysis and the fuzzy Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS). The management alternatives were presented spatially in the form of zoning maps at the level of irrigation zones of the study area. The results show that the irrigation management zone No.3 (alternative A3) was ranked first based on agricultural water demand and supply management in five among seven available scenarios, in which the scenarios represents a possible combination of weights assigned to the weighing criteria. Specifically, the results show that irrigation management zone No.3 (alternative A3) achieved the best ranking values of 0.151, 0.169, 0.152, 0.174 and 0.164 with respect to scenarios 1, 4, 5, 6 and 7, respectively. However, irrigation management zone No.2 (alternative A2) achieved the best values of 0.152 and 0.150 with respect to the second and third scenarios, respectively. The model results identify the best management alternatives for agricultural water management in large-scale irrigation and drainage networks.