RATIONALE:Recent studies have supported the safety and efficacy of psychedelic therapy for mood disorders and addiction. Music is considered an important component in the treatment model, but little empirical research has been done to examine the magnitude and nature of its therapeutic role. OBJECTIVES:The present study assessed the influence of music on the acute experience and clinical outcomes of psychedelic therapy. METHODS:Semi-structured interviews inquired about the different ways in which music influenced the experience of 19 patients undergoing psychedelic therapy with psilocybin for treatment-resistant depression. Interpretative phenomenological analysis was applied to the interview data to identify salient themes. In addition, ratings were given for each patient for the extent to which they expressed "liking," "resonance" (the music being experienced as "harmonious" with the emotional state of the listener), and "openness" (acceptance of the music-evoked experience). RESULTS:Analyses of the interviews revealed that the music had both "welcome" and "unwelcome" influences on patients' subjective experiences. Welcome influences included the evocation of personally meaningful and therapeutically useful emotion and mental imagery, a sense of guidance, openness, and the promotion of calm and a sense of safety. Conversely, unwelcome influences included the evocation of unpleasant emotion and imagery, a sense of being misguided and resistance. Correlation analyses showed that patients' experience of the music was associated with the occurrence of "mystical experiences" and "insightfulness." Crucially, the nature of the music experience was significantly predictive of reductions in depression 1 week after psilocybin, whereas general drug intensity was not. CONCLUSIONS:This study indicates that music plays a central therapeutic function in psychedelic therapy.

The article The hidden therapist: evidence for a central role of music in psychedelic therapy, written by Mendel Kaelen, Bruna Giribaldi, Jordan Raine, Lisa Evans, Christopher Timmerman, Natalie Rodriguez, Leor Roseman, Amanda Feilding, David Nutt, Robin Carhart-Harris, was originally published electronically on the publisher's internet portal.

Justice-oriented climate activism is proliferating. Many scholars aspire to deliver research that supports activism. However, measures of impact for research evaluation and funding purposes place little weight on the use of research by activists. Here we consider how academics and academia might effectively support and enable climate activism. We report outcomes from a series of online deliberative workshops involving both activists and academics from several European countries. The workshops were facilitated to create space for discussion, sharing of experiences and the development of proposals for the future. The outcomes take the form of a set of principles (a “minifesta”) for academic-activist engagement generated by the group. In discussing the process and outputs, we argue that a focus on inclusion can support politically transformative change of the scale and urgency required. We suggest that this also demands a shift in attitudes toward the role of activism and activists in collaborative processes. We further discuss the inevitable incompleteness of this process, arguing that incompleteness is, itself, a feature of inclusive engagement. We conclude that scholars working on climate issues in any discipline could benefit from increasing mutually supportive collaboration with activists; and that such collaboration and inclusion could help liberate democracy from authoritarian tendencies and market influences. Collaborative engagements generate legitimate, rich, and impactful outcomes even with the limitations posed by COVID19. We, therefore, commend both the model of engagement and the principles it generated for our colleagues and peers.