The 2017 Sustainable LA Grand Challenge Environmental Report Card (ERC) for Los Angeles County (LA County) on Energy and Air Quality offers an in-depth look at the region’s sustainability efforts focusing on the energy we use, greenhouse gas emissions, and the air we breathe. The LA County Environmental Report Card is the only comprehensive environmental report card for a megacity in the world. This ERC assesses 21 indicators that fall into five categories: Stationary Energy Use; Transportation; Renewable Energy Resources; Greenhouse Gas Emissions; and Air Quality and Human Health Impacts. A majority of these indicators are entirely new areas of inquiry for the ERC, and together will provide a broader picture of current conditions compared to the 2015 ERC. Grades were assigned in each category based on compliance with environmental laws or numeric standards where applicable, on our best professional judgment, and on historical improvements and context. This year’s grades range from C-/ Incomplete to B, and although there is progress towards meeting local and state goals, and a number of new standards and regulations that will undoubtedly have a positive impact in years to come.

UCLA launched its first Grand Challenge: Sustainable LA – Thriving in a Hotter Los Angeles, a novel and ambitious campus-wide research endeavor to tackle sustainability in Los Angeles County through innovations in science, technology, and policy. The Sustainable LA Grand Challenge aligns faculty, researchers, students, partner institutions, managers, policymakers, and community stakeholders around the objective of developing a research-based action plan to achieve three key goals in Los Angeles County by 2050:Power 100 percent of energy and transportation needs withrenewable energy; obtain 100 percent of water supply from sources within LosAngeles County; and to enhance ecosystem health together with human health and wellbeing. As outlined in the Five-Year Work Plan, between 2015-2020, UCLA faculty, researchers, students, and numerous partners will pursue more than 100 innovative research projects critical to charting a pathway for Los Angeles County to achieve the Sustainable LA Grand Challenge goals by 2050.

We have previously described a phenomenon called the death spiral that is characterized by a rapid decline in female fecundity 6-15 days prior to death in Drosophila. To carry out destructive physiological analyses of females in the death spiral would require a method to reliably classify individual females via the prediction of their age at death. Using cohorts of Drosophila we describe how to use the observed mortality prior to some target day and a female's fecundity 3 days prior to the target day to determine if the female is in the death spiral. The method works at all ages and although the method does not result in perfect classification, with sufficient sample sizes any physiological trait whose means differ between the groups can be detected.

The Sustainable LA Grand Challenge (SLA GC) Environmental Report Card (ERC) for Los Angeles County (L.A. County) is the only comprehensive environmental report card for a megacity in the world. This 2019 ERC on Water provides an in-depth look at the region's efforts in moving toward a more resilient local water supply, which requires maximizing high-quality local water supplies, improving water conveyance and treatment infrastructure, reducing water consumption, and implementing innovative technology and policy solutions. Twenty indicators were assessed across eight categories. Many of these indicators are new areas of assessment for the ERC and will provide a more comprehensive picture of current conditions compared to the 2015 ERC that last assessed L.A. County’s water. Grades were assigned in each category based on compliance with environmental laws or numeric standards where applicable, on our best professional judgment, and on historical improvements and context. This year’s grades range from D/ Incomplete to B+, and although there has been great progress in some areas, others still require significant improvement to raise the county’s C+ average.

There is now a significant body of research that establishes the deceleration of mortality rates in late life and their ultimate leveling off on a late-life plateau. Natural selection has been offered as one mechanism responsible for these plateaus. The force of natural selection should also exert such effects on female fecundity. We have already developed a model of female fecundity in late life that incorporates the general predictions of the evolutionary model. The original evolutionary model predicts a decline in fecundity from a peak in early life, followed by a plateau with non-zero fecundity in late life. However, in Drosophila there is also a well-defined decline in fecundity among dying flies, here called the "death spiral". This effect produces heterogeneity between dying and non-dying flies. Here a hybrid evolutionary heterogeneity model is developed to accommodate both the evolutionary plateau prediction and the death spiral. It is shown that this evolutionary heterogeneity model gives a much better fit to late-life fecundity data.

Evolutionary theory suggests that fecundity rates will plateau late in life in the same fashion as mortality rates. We demonstrate that late-life plateaus arise for fecundity in Drosophila melanogaster. The result qualitatively fits the evolutionary theory of late life based on the force of natural selection. But there are a number of alternative interpretations. Fecundity plateaus could be secondary consequences of mortality-rate plateaus. Female fecundity plateaus might arise from diminished male sexual function. Another alternative hypothesis is analogous to male sexual inadequacy: nutritional shortfalls. These may arise later in life because of a decline in female feeding or digestion. If some females have a life-long tendency to lay eggs at a faster rate, but die earlier, then aging for fecundity could arise from the progressive loss of the fast-layers, with the late-life plateau simply the laying patterns of individual females who were slow-layers throughout adult life. If this type of model is generally applicable to late life, then we should find that the females who survive to lay at a slow but steady rate in late life have a similar laying pattern in mid-life.

Late life is a distinct phase of life that occurs after the aging period and is now known to be general among aging organisms. While aging is characterized by a deterioration in survivorship and fertility, late life is characterized by the cessation of such age-related deterioration. Thus, late life presents a new and interesting area of research not only for evolutionary biology but also for physiology. In this article, we present the theoretical and experimental background to late life, as developed by evolutionary biologists and demographers. We discuss the discovery of late life and the two main theories developed to explain this phase of life: lifelong demographic heterogeneity theory and evolutionary theory based on the force of natural selection. Finally, we suggest topics for future physiological research on late life.

In 1966, William D. Hamilton published a landmark paper in evolutionary biology: "The Moulding of Senescence by Natural Selection." It is now apparent that this article is as important as his better-known 1964 articles on kin selection. Not only did the 1966 article explain aging, it also supplied the basic scaling forces for natural selection over the entire life history. Like the Lorentz transformations of relativistic physics, Hamilton's Forces of Natural Selection provide an overarching framework for understanding the power of natural selection at early ages, the existence of aging, the timing of aging, the cessation of aging, and the timing of the cessation of aging. His twin Forces show that natural selection shapes survival and fecundity in different ways, so their evolution can be somewhat distinct. Hamilton's Forces also define the context in which genetic variation is shaped. The Forces of Natural Selection are readily manipulable using experimental evolution, allowing the deceleration or acceleration of aging, and the shifting of the transition ages between development, aging, and late life. For these reasons, evolutionary research on the demographic features of life history should be referred to as "Hamiltonian."

An important aspect of the aging process in Drosophila melanogaster is the natural loss of antennae, legs, bristles, and parts of wings with age. These injuries lead to a loss of hemolymph, which contains water and nutrients. Stress-resistant lines of D. melanogaster are sometimes longer-lived than the populations from which they are derived. One hypothesis tested here is that increased stress-resistance fosters longevity because it allows fruit flies to cope with the loss of hemolymph due to injury to the aging fly. We tested the effects of surgically induced injury on the aging and reproduction of five replicate populations. We then tested the effects of injury on populations that had been selected for different levels of stress resistance and on control populations. Injury affected aging more in males than in females, in part because of a counter-balancing reduction in female reproduction brought about by injury. More specifically, injury reduced female fecundity and male virility. Injury significantly reduced the starvation resistance in some groups of flies, but not in others. These findings undermine any simple interpretation of the interactions between injury, reproduction, and aging based on stress resistance. But they do indicate the existence of significant interactions between these biological processes, interactions that should be resolved in greater mechanistic detail than has been managed here.