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Scholarly Works (1 results)

Article
Peer Reviewed

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.

Finkbeiner, Steven;
Tóth, G;
Gardai, SJ;
Zago, W;
Bertoncini, CW;
Cremades, N;
Roy, SL;
Tambe, MA;
Rochet, J-C;
Galvagnion, C;
Skibinski, G

UC San Francisco Previously Published Works (2014)

The misfolding of intrinsically disordered proteins such as α-synuclein, tau and the Aβ peptide has been associated with many highly debilitating neurodegenerative syndromes including Parkinson's and Alzheimer's diseases. Therapeutic targeting of the monom