Established in 2006, the Chickasaw Press is the first tribally owned and operated publishing house in the United States. This article recounts the history of this innovative Indigenous enterprise, explores its decolonized practices and publications, and connects the press to national initiatives for American Indian cultural revitalization. In doing so, I reveal how the press serves as an active agent in the movement for Indigenous cultural and intellectual sovereignty and showcase how this outlet brings together traditional knowledge and cutting-edge technologies to decenter colonial narratives about the Chickasaw people and, thus, to reinstate Chickasaw tribal knowledge and perspectives.