Participants in most binary-choice tasks with multiple trialstend to probability-match (Vulkan, 2000) — i.e., provide re-sponses that match the probability distribution of the presentedpopulation. Given a single trial, however, participants usuallychoose the majority option (James & Koehler, 2011). By us-ing a method that visually presents the probabilities of the twocompeting options, we examine responses when participantsare given only a single trial, and initial responses when partic-ipants are given multiple trials. While we still observe aggre-gate probability-matching in the multiple-trial condition, wefind robust sequence effects in participants’ initial responses,including robust maximizing behavior on the first response.This suggests that both maximizing in single-trial experimentsand aggregate probability-matching in multiple-trial ones canbe explained by a single, underlying mechanism; one thatseeks to provide a representative sample at each point duringsequence generation.

Autophagy is essential to cell function, as it enables the recycling of intracellular constituents during starvation and in addition functions as a quality control mechanism by eliminating spent organelles and proteins that could cause cellular damage if not properly removed. Recently, we reported on Wdfy3's role in mitophagy, a clinically relevant macroautophagic scaffold protein that is linked to intellectual disability, neurodevelopmental delay, and autism spectrum disorder. In this study, we confirm our previous report that Wdfy3 haploinsufficiency in mice results in decreased mitophagy with accumulation of mitochondria with altered morphology, but expanding on that observation, we also note decreased mitochondrial localization at synaptic terminals and decreased synaptic density, which may contribute to altered synaptic plasticity. These changes are accompanied by defective elimination of glycogen particles and a shift to increased glycogen synthesis over glycogenolysis and glycophagy. This imbalance leads to an age-dependent higher incidence of brain glycogen deposits with cerebellar hypoplasia. Our results support and further extend Wdfy3's role in modulating both brain bioenergetics and synaptic plasticity by including glycogen as a target of macroautophagic degradation.