We demonstrate random laser (RL) emission from within bovine pericardium (BP) tissue. The interest in BP relies on its wide use as a valve replacement and as a biological patch. By imaging the emitting tissue, we show that RL emission is mostly generated inside the collagen fibers. Multimode RL operation is thus achieved within the volume of each fiber. Image analysis reveals that the intensity of the RL emission from individual fibers is dependent on the relative orientation to the stress axis. Our results suggest that RL intensity may be used as an indicator of stress concentration in individual fibers.