Jet quenching has become an essential signal for the characterization of the medium formed in experiments of heavy-ion collisions. After a brief introduction to the field, we present the full derivation of the medium-induced gluon radiation spectrum, starting from the diagrammatical origin of the Wilson lines and the medium averages and including all intermediate steps. The application of this spectrum to actual phenomenological calculations is then presented, making comparisons with experimental data and indicating some improvements of the formalism to the future LHC program. The last part of the lectures reviews calculations based on the AdS/CFT correspondence on the medium parameters controlling the jet quenching phenomenon.