Skip to main content
eScholarship
Open Access Publications from the University of California

Scholarly Works (2 results)

  • Thesis
  • Peer Reviewed
UC San Diego Electronic Theses and Dissertations (2020)

Ulcerative Colitis is a disease characterized by chronic inflammation within the digestive tract of humans. This disease can have everlasting implications on a persons quality of life and can cause patients to make regular visits to the clinic to ensure their health is not deteriorating which typically results in an endoscopy which is invasive, time consuming, and expensive. Here we explore a multi-omic data set using machine learning and statistics in hopes to find biomarkers that may be indicative of histological remission. Exploring multiple different omic data allowed us to take a holistic view at the protein composition of the cohort that was being studies, ultimately deciding to pursue serum proteins for ease of obtaining samples from patients. We see that there are proteins that are a present within the patients serum that need to be further studied due to their relation to an immune response indicative of processes relating to remission.

    Cover page: Biomarker Discovery for Ulcerative Colitis
    • Article
    • Peer Reviewed
    UC San Diego Previously Published Works (2019)
    The ability to reproduce early stages of human neurodevelopment in the laboratory is one of the most exciting fields in modern neuroscience. The inaccessibility of the healthy human brain developing in utero has delayed our understanding of the initial steps in the formation of one of the most complex tissues in the body. Animal models, postmortem human tissues and cellular systems have been instrumental in contributing to our understanding of the human brain. However, all model systems have intrinsic limitations. The emerging field of brain organoids, which are three-dimensional self-assembled multicellular structures derived from human pluripotent stem cells, offers a promising complementary cellular model for the study of the human brain. Here, we will discuss the initial experiments that were the foundation for this emerging field, highlight recent uses of the technology and offer our perspective on future directions that might guide further exploratory experimentation to improve the human brain organoid model system.
      Cover page: Brain organoids as a model system for human neurodevelopment and disease
      Top