The misinformation effect occurs when people's memory of an event is altered by subsequent inaccurate information. No study has systematically tested theories about the dynamics of human hippocampal representations during the three stages of misinformation-induced false memory. This study replicates behavioral results of the misinformation effect, and investigates the cross-stage pattern similarity in the hippocampus and cortex using functional magnetic resonance imaging. Results show item-specific hippocampal pattern similarity between original-event and post-event stages. During the memory-test stage, hippocampal representations of original information are weakened for true memory, whereas hippocampal representations of misinformation compete with original information to create false memory. When false memory occurs, this conflict is resolved by the lateral prefrontal cortex. Individuals' memory traces of post-event information in the hippocampus predict false memory, whereas original information in the lateral parietal cortex predicts true memory. These findings support the multiple-trace model, and emphasize the reconstructive nature of human memory.

Theoretical and computational models such as transfer-appropriate processing (TAP) and global matching models have emphasized the encoding-retrieval interaction of memory representations in generating false memories, but relevant neural mechanisms are still poorly understood. By manipulating the sensory modalities (visual and auditory) at different processing stages (learning and test) in the Deese-Roediger-McDermott task, we found that the auditory-learning visual-test (AV) group produced more false memories (59%) than the other three groups (42∼44%) [i.e., visual learning visual test (VV), auditory learning auditory test (AA), and visual learning auditory test (VA)]. Functional imaging results showed that the AV group's proneness to false memories was associated with (i) reduced representational match between the tested item and all studied items in the visual cortex, (ii) weakened prefrontal monitoring process due to the reliance on frontal memory signal for both targets and lures, and (iii) enhanced neural similarity for semantically related words in the temporal pole as a result of auditory learning. These results are consistent with the predictions based on the TAP and global matching models and highlight the complex interactions of representations during encoding and retrieval in distributed brain regions that contribute to false memories.