In northern Laos, shortened fallows in the slash-and-burn upland rice system are not sustainable either from a production or economic standpoint. This paper evaluates the potential for using the indigenous fast-growing tree, Broussonetia papyrifera L. Vent. (paper mulberry) as an economic fallow crop. The objectives of this study are to assess the inner bark yield of paper mulberry, and to evaluate rice productivity following paper mulberry cultivation. In addition, allometric models for estimating the inner bark yield of paper mulberry are developed. Inner bark yield of paper mulberry stands ranging in age from 9 to 48 months ranged from 10 to 208 g m−2, and increased with age. The models using diameter at breast height and stem height, or diameter at breast height only as independent variables explained well the variation in inner bark yield. When paper mulberry was completely removed during the rice growing season, rice yields in these areas were similar to those following weedy bush fallow. When paper mulberry was allowed to grow, rice yields were negatively correlated to paper mulberry stem density. When paper mulberry lateral branches were pruned back, rice yields could be maintained if the paper mulberry stem density was <0.22 stems m−2, suggesting that if paper mulberry is managed properly, rice yields can be maintained at current levels. The paper mulberry-upland rice rotation system improves the productivity of a traditional slash-and-burn system through harvesting paper mulberry inner bark; however the long-term sustainability of such a system remains unclear and warrants further investigation.

Background

The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry.

Methods and results

A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up.

Conclusion

Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362.