The purpose of our research study was to determine the social and ethical aspects of genetic engineering. What originally began as a way to decrease an embryo's risk of genetic diseases has now become a way to alter its appearance; this paper aims to challenge the risks of genetic engineering. To dive deeper into our research question, we were able to examine sources on a global level to determine the perspectives of genetic engineering in different parts of the world. As the current field of genetic engineering is under speculation by many providers, evaluating the pros and cons of each scenario can determine the efficacy of genetic engineering. Employing clinical technology and socially ethical framework were two main criterias which were used in determining the parameters in understanding if genetic engineering is a viable treatment option. The research examined explains any known sideaffects, while also bringing to light the unknown side effects that can result from genetic alterations of an embryo. In summation, this paper aims to highlight embryonic effects and how genetic engineering could challenge their integration into society itself.

Bisphenol A (BPA) is an industrial plasticizer widely found in consumer products, and exposure to BPA during early development has been associated with the prevalence of various cardiometabolic diseases including obesity, metabolic syndrome, type 2 diabetes, and cardiovascular diseases. To elucidate the molecular perturbations underlying the connection of low-dose prenatal BPA exposure to cardiometabolic diseases, we conducted a multi-dimensional systems biology study assessing the liver transcriptome, gut microbial community, and diverse metabolic phenotypes in both male and female mouse offspring exposed to 5 μg/kg/day BPA during gestation. Prenatal exposure to low-dose BPA not only significantly affected liver genes involved in oxidative phosphorylation, PPAR signaling and fatty acid metabolism, but also affected the gut microbial composition in an age- and sex-dependent manner. Bacteria such as those belonging to the S24-7 and Lachnospiraceae families were correlated with offspring phenotypes, differentially expressed liver metabolic genes such as Acadl and Dgat1, and key drivers identified in our gene network modeling such as Malat1 and Apoa2. This multiomics study provides insight into the relationship between gut bacteria and host liver genes that could contribute to cardiometabolic disease risks upon low-dose BPA exposure.