The mission of the Branch of Animal Control, Division of Wildlife Services, Bureau of Sport Fisheries & Wildlife, U.S. Department of the Interior, is discussed. While there is an ever-increasing need to protect agricultural products both at home and abroad, as well as to protect human health and safety, there is also a real concern to reduce impacts of animal control on the environment and on nontarget wildlife, in particular. We need techniques and materials that are more selective, and control needs to be based on demonstrated need. Compound 1339 is in the last stages of registration and promises appreciable relief from starling problems, particularly in feedlot situations. Compound 714, “Gophacide,” has been registered and will serve as a replacement for Compound 1080 in the control of certain burrowing rodents, as it substantially reduced secondary hazards. Compound 1080 remains the most effective and selective tool for controlling coyotes., with significant advantages over strychnine or trapping. Aerial hunting is now used more than ever and is a selective method. The agency’s new responsibilities in the areas of pesticide surveillance and in wildlife enhancement are discussed.