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Fusion of a short peptide that binds immunoglobulin G to a recombinant protein substantially increases its plasma half-life in mice

UC San Francisco Previously Published Works (2014)

We explore a strategy to substantially increase the half-life of recombinant proteins by genetic fusion to FcIII, a 13-mer IgG-Fc domain binding peptide (IgGBP) originally identified by DeLano and co-workers at Genentech [DeLano WL, et al. (2000) Science 2

Article
Peer Reviewed

Branched cationic peptides for gene delivery:: Role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes (vol 10, pg 322, 1999)

UC San Francisco Previously Published Works (1999)

Cover page: Branched cationic peptides for gene delivery:: Role of type and number of cationic residues in formation and <i>in vitro</i> activity of DNA polyplexes (vol 10, pg 322, 1999)

Article
Peer Reviewed

Chemoenzymatic synthesis of oligohyaluronan-lipid conjugates

UC San Francisco Previously Published Works (2014)

Herein, we describe an efficient and high-yielding method to synthesize hyaluronan oligosaccharide-lipid conjugates. This strategy is based on first covalently attaching diphytanoyl glycerophosphatidylethanolamine (DiPhPE) to commercially available high mo

Article
Peer Reviewed

Intravitreal Administration of HA-1077, a ROCK Inhibitor, Improves Retinal Function in a Mouse Model of Huntington Disease

UC San Francisco Previously Published Works (2013)

Huntington disease (HD) is an inherited neurodegenerative disease that affects multiple brain regions. It is caused by an expanded polyglutamine tract in huntingtin (Htt). The development of therapies for HD and other neurodegenerative diseases has been ha