Performance quantification through simulation has been particularly advantageous to building design, as it can be applied to non-existent buildings in the design process, allows for testing design variants under identical conditions, and demands much less resources as compared to physical measurements. Consequently, use of building simulation in the design process has evolved to – for example – establish and verify design performance, screen and optimize design parameters, and study robustness and adaptability in adverse conditions. In this context, the present chapter investigates how the state-of-the-art simulation-aided design procedures can contribute to realize occupant-centric design objectives. To this end, the chapter, first, discusses the ways in which simulation-aided design methods can represent occupants and capture their interactions with buildings' environmental control systems. Subsequently, a number of key simulation-aided design methods and objectives are explored with a focus on the role of occupants. Finally, a carefully described prototypical building model serves to demonstrate and test the introduced occupant-centric simulation-aided design procedures.