Self-rated anti-American Indian attitudes were examined for the influence on domestic violence culpability perceptions when the domestic violence actors’ race (American Indian or European American) and alcohol use (intoxicated or not) were varied. Those higher in anti-American Indian attitudes produced more negative culpability ratings concerning American Indian women involved in domestic violence than those low in American Indian bias. This has implications for health system treatment and legal interventions and processing. Education concerning American Indian cultural issues and biases against them is needed for those working with American Indian health and justice systems.