- Erdeve, Omer;
- Division of Neonatology, Department of Pediatrics;
- Okulu, Emel;
- Singh, Yogen;
- Sindelar, Richard;
- Oncel, Mehmet Yekta;
- Terrin, Gianluca;
- Boscarino, Giovanni;
- Bulbul, Ali;
- Sallmon, Hannes;
- Atasay, Begum;
- Ovali, Fahri;
- Clyman, Ronald I;
- Division of Neonatology, Loma Linda University School of Medicine;
- Cambridge University Hospitals NHS Foundation Trust, Cambridge;
- Department of Women’s and Children’s Health, Uppsala University;
- Division of Neonatology, Buca Seyfi Demirsoy Training and Research Hospital;
- Division of Neonatology, Department of Pediatrics;
- Department of Maternal and Child Health, University of Roma La Sapienza;
- Division of Neonatology, Department of Pediatrics University of Health Science;
- Department of Congenital Heart Disease/Pediatric Cardiology, Charité–Universitätsmedizin Berlin and Deutsches Herzzentrum Berlin;
- Division of Neonatology, Department of Pediatrics;
- Department of Pediatrics and Cardiovascular Research Institute, University of California San Francisco
Patent ductus arteriosus is the most common cardiovascular condition in preterm infants. There is a significant uncertainty about when and how to close ductus arteriosus in preterm infants due to a high spontaneous closure rate even in very immature preterm infants. Diagnosis and management of patent ductus arteriosus remain a challenge for both neonatologists and pediatric cardiologists. Researchers have tried to define a balance between an expectant approach and active treatment in selected infants. This review aimed to focus on the pathophysiology and management of patent ductus arteriosus and to make suggestions about approaches that might eliminate the association of morbidities with patent ductus arteriosus.
