The primary objective of the present paper is to explore the patriotic resistance movement of the Mareko people of south-central Ethiopia against Italy’s colonialist aggression and five-year occupation between 1935 and 1941. The paper also uncovers the role played by the Mareko people and other ethno-linguistic individual freedom fighters who opposed the Fascist administration within the Mareko woreda (district). Though the then governor of the Dobena sub-district and his officers became the leading collaborators (banda) with the Fascist administrators, the majority of the Mareko people strongly resisted these detractors. Like other nations, nationalities and peoples of Ethiopia, the estimated 110 Mareko marched against the invaders at the battle of Maychew in 1936 despite enduring major casualties. Acknowledging the local spiritual leadership of Wärѐqѐ Märeyamѐ and Qegnazmach Tuji Anjilo, this paper celebrates the local Mareko defiance in staving off the encroaching Italian regime’s divide and rule tactics specifically, and retaliatory colonialism in general.