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Open Access Publications from the University of California

Scholarly Works (2 results)

  • Article
  • Peer Reviewed
UC San Francisco Previously Published Works (2022)
The study of the epitranscriptome has thus far focused largely on mRNA methylation. Recent human genetics studies suggest that methylation of ribosomal RNA also contributes to brain development and cognition. In particular, the m6A modification at the A-1832 position of the 18S rRNA is installed by METTL5. Mutations or deletions of Mettl5 in humans and mice, respectively, cause abnormal translation and gene expression that in turn mediates stem cell behaviors such as differentiation. In this review, we provide an overview of the current knowledge of the methyltransferase METTL5, as well as the molecular biology surrounding m6A on rRNA and how it regulates cell behavior.
    Cover page: The emerging importance of METTL5-mediated ribosomal RNA methylation
    • Thesis
    • Peer Reviewed
    UC San Diego Electronic Theses and Dissertations (2019)

    An internal time keeping mechanism known as the circadian clock allows organisms to anticipate changes in the environment (Michael et al., 2003; Dodd, 2005). Environmental stressors have been shown to disrupt the circadian clock so it cannot accurately predict those changes. For example, a previous study revealed that a Pseudomonas syringae infection altered the clock, leading to long period and dampened circadian rhythms (Li et al., 2018). These clock phenotypes were triggered by host and pathogen responses (Li et al., 2018). In this thesis, we explored the molecular mechanisms that regulate the observed clock phenotypes upon infection. We found that pathogen-triggered responses directly target clock components, which likely results in the observed clock phenotypes. Such results suggest that, at least in plants, the outcome of host-pathogen interactions relies on the control of the circadian clock function.

      Cover page: Regulation of the Circadian Clock Function in Arabidopsis thaliana by the Bacterial Pathogen Pseudomonas syringae
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