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Open Access Publications from the University of California

Scholarly Works (73 results)

  • Thesis
  • Peer Reviewed
UC San Diego Electronic Theses and Dissertations (2022)

Individuals diagnosed with Mild Cognitive Impairment (MCI) are at a higher risk for conversion to dementia and, therefore, may be particularly motivated/well-suited to participate in interventions to slow cognitive decline. Cognitive and lifestyle interventions targeting modifiable risk factors (e.g., physical activity [PA] and sleep) can slow the rate of cognitive decline. Psychometrically validated subjective indices of PA and sleep offer a practical and economical method of assessing these cognitively salient lifestyle factors in the context of longitudinal studies of older adults with MCI. Moreover, the burgeoning availability of inexpensive, accurate wearable devices to measure lifestyle behaviors makes valid, unobtrusive objective measurement of these outcomes possible. Thus, this dissertation study examined the efficacy of an 8-week Motivationally Enhanced Compensatory Cognitive Training (ME-CCT) intervention, compared to Goal-focused Supportive Contact (SC), in improving subjectively and objectively measured lifestyle factors in older Veterans with MCI.Self-reported sleep disturbance and PA levels were examined at baseline, mid-treatment, and post-treatment in 74 Veterans with MCI enrolled as part of a larger randomized controlled trial. Sleep and PA were objectively measured via the Fitbit Charge 2 in a subset of the sample (n=23). Mixed-effects models examined whether (1) ME-CCT, compared to SC, was associated with greater improvements in self-rated PA levels and sleep disturbance; and (2) baseline levels of self-rated PA and sleep disturbance moderated treatment effects on these outcomes. Exploratory analyses examined baseline-level correlates of Fitbit-measured PA and sleep, and the efficacy of ME-CCT in improving objective PA/sleep. There was no differential treatment-related improvement in either subjective or objective measures of PA or sleep, with no treatment-moderating effect of baseline PA/sleep (ps>.05). At baseline, greater self-reported engagement in PA (rs=0.57, p=.005) and less executive dysfunction (r=-0.43, p=.043) were associated with greater Fitbit step counts. Moreover, higher pain intensity (r=-0.49, p=.048) was associated with shorter Fitbit sleep duration. ME-CCT did not differentially improve sleep or PA levels, nor did baseline levels of sleep/PA influence treatment outcomes. The influence of pain intensity and executive deficits, such as planning and organizing, in moderating trajectories in cognitive and health behavior engagement should be considered in current rehabilitation efforts in aging.

    Cover page: Effects of Motivationally Enhanced Compensatory Cognitive Training on modifiable risk factors for Mild Cognitive Impairment
    • Article
    • Peer Reviewed
    UC San Diego Previously Published Works (2015)

    Background

    The degree to which people with schizophrenia show awareness of cognitive dysfunction and whether this neurocognitive insight affects treatment use or outcome is understudied. We aimed to examine neurocognitive insight among a treatment-seeking sample of patients with psychotic disorders, and whether neurocognitive insight affected treatment utilization or outcome.

    Method

    69 individuals with schizophrenia-spectrum disorders enrolled in a trial comparing Compensatory Cognitive Training (CCT) to standard pharmacotherapy. Participants with objective cognitive impairment were identified and grouped into "intact" vs. "impaired" neurocognitive insight groups. These groups were then compared via ANCOVA on three treatment utilization variables and six post-treatment cognitive/functional variables.

    Results

    43 participants demonstrated objective cognitive impairment. Among those individuals, 31 were considered to have intact neurocognitive insight and 12 showed impaired neurocognitive insight. These two groups did not differ on CCT attendance, satisfaction with the intervention, or self-reported cognitive strategy use at post-treatment. There were significant treatment group by neurocognitive insight group interactions for verbal memory and functional capacity outcomes, such that individuals with impaired neurocognitive insight who received treatment performed better than those who did not receive treatment.

    Conclusions

    Even among individuals who self-select into a cognitive treatment study, many show minimal awareness of cognitive dysfunction. Impaired neurocognitive insight, however, was not associated with decreased treatment utilization, and was associated with positive treatment outcomes in some cognitive domains as well as functional capacity. As cognitive training treatments become increasingly available, impaired neurocognitive insight need not be a barrier to participation.
      Cover page: Neurocognitive insight, treatment utilization, and cognitive training outcomes in schizophrenia
      • Article
      • Peer Reviewed
      UC San Diego Previously Published Works (2004)

      Previous research on the neuropsychology of posttraumatic stress disorder (PTSD) has identified several neurocognitive deficits that co-occur with the disorder. However, it remains unclear whether these deficits are due to trauma exposure, PTSD symptomatology or psychiatric/substance abuse comorbidity. We examined trauma exposure, PTSD symptoms and neuropsychological performance in 235 undergraduate students, i.e. a non-clinical sample. The sample comprised 146 subjects with trauma exposure (38 with current PTSD and 108 without lifetime PTSD) and 89 no-trauma comparison (NC) subjects who were administered tests of attention, working memory, psychomotor speed, word generation and executive functioning. Relationships of neuropsychological functioning to measures of psychiatric symptoms and substance abuse were examined. Current PTSD (PTSD+), trauma-exposed without PTSD (PTSD-) and NC subjects did not differ significantly on the vast majority of neuropsychological tests. There were very few significant associations between neuropsychological performance and clinical variables, and those that were statistically significant were small in magnitude. The striking lack of differences in neuropsychological performance between the three groups suggests that college students with trauma exposure, regardless of the presence of PTSD symptoms, may be cognitively resilient. Neuropsychological impairment may not be an invariant feature of PTSD, but when it is present, it may be associated with poorer functional outcomes. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

        Cover page: Neuropsychological function in college students with and without posttraumatic stress disorder
        • Article
        • Peer Reviewed
        UC San Diego Previously Published Works (2018)
        Neuropsychological abilities may underlie successful performance of everyday functioning and social skills. We aimed to determine the strongest neuropsychological predictors of performance-based functional capacity and social skills performance across the spectrum of severe mental illness (SMI). Unemployed outpatients with SMI (schizophrenia, bipolar disorder, or major depression; n = 151) were administered neuropsychological (expanded MATRICS Consensus Cognitive Battery), functional capacity (UCSD Performance-Based Skills Assessment-Brief; UPSA-B), and social skills (Social Skills Performance Assessment; SSPA) assessments. Bivariate correlations between neuropsychological performance and UPSA-B and SSPA total scores showed that most neuropsychological tests were significantly associated with each performance-based measure. Forward entry stepwise regression analyses were conducted entering education, diagnosis, symptom severity, and neuropsychological performance as predictors of functional capacity and social skills. Diagnosis, working memory, sustained attention, and category and letter fluency emerged as significant predictors of functional capacity, in a model that explained 43% of the variance. Negative symptoms, sustained attention, and letter fluency were significant predictors of social skill performance, in a model explaining 35% of the variance. Functional capacity is positively associated with neuropsychological functioning, but diagnosis remains strongly influential, with mood disorder participants outperforming those with psychosis. Social skill performance appears to be positively associated with sustained attention and verbal fluency regardless of diagnosis; however, negative symptom severity strongly predicts social skills performance. Improving neuropsychological functioning may improve psychosocial functioning in people with SMI.
          Cover page: Neuropsychological predictors of performance-based measures of functional capacity and social skills in individuals with severe mental illness
          • Article
          • Peer Reviewed
          UC San Diego Previously Published Works (2024)
          Abstract This study compared findings from whole-brain diffusion tensor imaging (DTI) and volumetric magnetic resonance imaging (MRI) among 90 Active Duty Service Members with chronic mild traumatic brain injury (TBI; n = 52), chronic moderate-to-severe TBI (n = 17), and TBI-negative controls (n = 21). Data were collected on a Philips Ingenia 3T MRI with DTI in 32 directions. Results demonstrated that history of TBI was associated with differences in white matter microstructure, white matter volume, and cortical thickness in both mild TBI and moderate-to-severe TBI groups relative to controls. However, the presence, pattern, and distribution of these findings varied substantially depending on the injury severity. Spatially-defined forms of DTI fractional anisotropy (FA) analyses identified altered white matter organization within the chronic moderate-to-severe TBI group, but they did not provide clear evidence of abnormalities within the chronic mild TBI group. In contrast, DTI FA pothole analyses identified widely distributed areas of decreased FA throughout the white matter in both the chronic mild TBI and chronic moderate-to-severe TBI groups. Additionally, decreased white matter volume was found in several brain regions for the chronic moderate-to-severe TBI group compared with the other groups. Greater number of DTI FA potholes and reduced cortical thickness were also related to greater severity of self-reported symptoms. In sum, this study expands upon a growing body of literature using advanced imaging techniques to identify potential effects of brain injury in military Service Members. These findings may differ from work in other TBI populations due to varying mechanisms and frequency of injury, as well as a potentially higher level of functioning in the current sample related to the ability to maintain continued Active Duty status after injury. In conclusion, this study provides DTI and volumetric MRI findings across the spectrum of TBI severity. These results provide support for the use of DTI and volumetric MRI to identify differences in white matter microstructure and volume related to TBI. In particular, DTI FA pothole analysis may provide greater sensitivity for detecting subtle forms of white matter injury than conventional DTI FA analyses.
            Cover page: White Matter Organization and Cortical Thickness Differ Among Active Duty Service Members With Chronic Mild, Moderate, and Severe Traumatic Brain Injury.
            • Article
            • Peer Reviewed
            UC San Diego Previously Published Works (2015)
            Homeless people experience elevated rates of risk factors for cognitive impairment. We reviewed available peer-reviewed studies reporting data from objective measures of cognition in samples identified as homeless. Pooled sample-weighted estimates of global cognitive screening measures, full-scale intelligence quotient (IQ), and premorbid IQ were calculated, in addition to pooled sample characteristics, to understand the representativeness of available studies. A total of 24 unique studies were identified, with 2969 subjects. The pooled estimate for the frequency of cognitive impairment was 25%, and the mean full-scale IQ score was 85, 1 standard deviation below the mean of the normal population. Cognitive impairment was found to be common among homeless adults and may be a transdiagnostic problem that impedes rehabilitative efforts in this population. Comparatively little data are available about cognition in homeless women and unsheltered persons.
              Cover page: A Quantitative Review of Cognitive Functioning in Homeless Adults
              • Article
              • Peer Reviewed
              UC San Diego Previously Published Works (2013)

              Rationale

              Impaired cognitive abilities are a key characteristic of schizophrenia. Although currently approved pharmacological treatments have demonstrated efficacy for positive symptoms, to date no pharmacological treatments successfully reverse cognitive dysfunction in these patients. Cognitively-based interventions such as cognitive remediation (CR) and other psychosocial interventions however, may improve some of the cognitive and functional deficits of schizophrenia. Given that these treatments are time-consuming and labor-intensive, maximizing their effectiveness is a priority. Augmenting psychosocial interventions with pharmacological treatments may be a viable strategy for reducing the impact of cognitive deficits in patients with schizophrenia.

              Objective

              We propose a strategy to develop pharmacological treatments that can enhance the reward-related learning processes underlying successful skill-learning in psychosocial interventions. Specifically, we review clinical and preclinical evidence and paradigms that can be utilized to develop these pharmacological augmentation strategies. Prototypes for this approach include dopamine D1 receptor and α7 nicotinic acetylcholine receptor agonists as attractive targets to specifically enhance reward-related learning during CR.

              Conclusion

              The approach outlined here could be used broadly to develop pharmacological augmentation strategies across a number of cognitive domains underlying successful psychosocial treatment.
                Cover page: Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: a roadmap for preclinical development
                • Article
                • Peer Reviewed
                UC San Diego Previously Published Works (2019)
                OBJECTIVE:Prospective memory (the ability to remember to do things) has clear implications for everyday functioning, including employment, in people with severe mental illnesses (SMI). This study aimed to evaluate prospective memory performance and its relationship to real-world functional variables in an employment-seeking sample of people with SMI (Clinical Trial registration number NCT00895258). METHOD:153 individuals with DSM-IV diagnosis of depression (n = 58), bipolar disorder (n = 37), or schizophrenia (n = 58) who were receiving outpatient psychiatric care at a university clinic enrolled in a trial of supported employment and completed a baseline assessment. Prospective memory was measured with the Memory for Intentions Test (MIST); real-world functional status included work history variables, clinical history variables, baseline functional capacity (UCSD Performance-based Skills Assessment-Brief), and work outcomes (weeks worked and wages earned during two years of supported employment). RESULTS:Participants with schizophrenia performed worse on the MIST than did those with affective disorders. Independent of diagnosis, education, and estimated intellectual functioning, prospective memory significantly predicted variance in measures of disability and illness burden (disability benefits, hospitalization history, current functional capacity), and work outcomes over two years of supported employment (weeks worked). CONCLUSIONS:Worse prospective memory appears to be associated with greater illness burden and functional disability in SMI. Mental health clinicians and employment specialists may counsel clients to use compensatory prospective memory strategies to improve work performance and decrease functional disability associated with SMI.
                  Cover page: Prospective memory, level of disability, and return to work in severe mental illness
                  • Article
                  • Peer Reviewed
                  UC San Diego Previously Published Works (2017)

                  Objective

                  This study explored whether age moderated cognitive, symptom, and functional changes over a 12-week compensatory cognitive training (CCT) intervention for participants with severe mental illnesses. CCT focused on the cognitive domains of attention, learning, prospective memory, and executive functioning, often impaired in this population.

                  Method

                  Seventy-seven unemployed individuals (46 participants with severe mood disorders and 31 participants with schizophrenia/schizoaffective disorder; mean age = 44 years) received CCT for 12 weeks in the context of a supported employment program. Participants were administered cognitive, symptom severity, and functional measures at baseline and 3-, 6-, and 12-month follow-ups, as well as at 18 and 24 months for symptom/functional measures. Mixed effects models, controlling for diagnosis, examined whether age impacted the trajectories of change following CCT.

                  Results

                  Analyses showed several significant time by age interactions; younger participants improved more over time on category fluency, β = -.280, t(42.10) = -2.76, p = .008, and financial capacity (UCSD Performance-Based Skills Assessment), β = -.194, t(54.02) = -2.21, p = .031, whereas older participants showed greater reduction in positive symptom severity (Positive and Negative Syndrome Scale), β = -.109, t(78.35) = -2.34, p = .022, and less functional decline on the Independent Living Skills Survey, β = .118, t(109.77) = 2.05, p = .043.

                  Conclusions and implications for practice

                  Age moderated the effects of CCT over time on measures of cognition, symptom severity, and functioning. Younger participants improved on objective measures of verbal processing speed and financial capacity, whereas older participants showed reduced positive symptom severity and less decline in self-reported daily functioning. These findings suggest that CCT may differentially benefit persons with severe mental illnesses depending on age. (PsycINFO Database Record
                    Cover page: Age as a Moderator of Change Following Compensatory Cognitive Training in Individuals With Severe Mental Illnesses
                    • Article
                    • Peer Reviewed
                    UC San Diego Previously Published Works (2016)
                    The objective of this study was to examine whether cognitive change and age predicted work outcome in the context of supported employment (SE) and compensatory cognitive training (CCT) in severe mental illness. Forty unemployed outpatients receiving SE (7 young [20-35 years], 15 middle-aged [36-50 years], and 18 older [51-66 years] patients) completed cognitive assessments at baseline and after 12 weeks of CCT. Logistic regression analyses showed that improvement in attention/vigilance significantly predicted work attainment (B = 2.35, SE = 1.16, p = 0.043). Young and older participants were more likely to obtain work than middle-aged participants (B = 4.03, SE = 1.43, p = 0.005; B = 2.16, SE = 0.93, p = 0.021, respectively). Improved attention and age group (young and old) were associated with better work outcomes after SE + CCT. Improving attention may be an important target for improving work outcome in severe mental illness. Middle-aged individuals may need additional support to return to work.
                      Cover page: Age and Improved Attention Predict Work Attainment in Combined Compensatory Cognitive Training and Supported Employment for People With Severe Mental Illness
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