Cultural mismatch theory predicts that a mismatch between the independent values of a higher education institution and the interdependent values of an underrepresented student may pose significant challenges for such students. This study examines the relationships between Greek membership, ethnic identity, perceptions of the university, persistence attitudes, and belonging. Latinx and multicultural-based fraternities and sororities are relatively small and may provide a sense of familismo for Latinx students, thus matching their culture and influencing factors of persistence. We expect that Latinx Greek members will show stronger positive relationships between ethnic identity, persistence, and belonging compared to non-Greek Latinx students.