The key challenge in cancer treatment is prevention of metastatic disease which is therapeutically resistant and carries poor prognoses necessitating efficacious prophylactic approaches that prevent metastasis and recurrence. It is previously demonstrated that cowpea mosaic virus (CPMV) induces durable antitumor responses when used in situ, i.e., intratumoral injection. As a new direction, it is showed that CPMV demonstrates widespread effectiveness as an immunoprophylactic agent - potent efficacy is demonstrated in four metastatic models of colon, ovarian, melanoma, and breast cancer. Systemic administration of CPMV stimulates the innate immune system, enabling attack of cancer cells; processing of the cancer cells and associated antigens leads to systemic, durable, and adaptive antitumor immunity. Overall, CPMV demonstrated broad efficacy as an immunoprophylactic agent in the rejection of metastatic cancer.

Virtual Reality (VR) technology has been widely used in researching situations that require high ecological validity but are difficult to copy. In this paper, we compare the effect of 360-degree videos in VR head-mounted display and 2D computer screen on evoking four types of emotional states, and innovatively assess the effect of emotion evoking using the Go/No-go attention paradigm. Based on the eye movement data collected from a considerable number of participants (N=48), the result reaches marginally significance in the effect of immersion level of evoking (p=0.075), emotion’s level of arousal (p=0.019), and the interaction between them (p=0.037) under the condition of positive evoking. We find that immersive device can better evoke positive emotions with high arousal, while non-immersive device cannot manipulate the intensity of evoked emotions. Our study empirically demonstrate that high-arousal positive emotion evoking is more effective in VR than on a 2D monitor based on computational affection.