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Open Access Publications from the University of California

Scholarly Works (4 results)

  • Article
  • Peer Reviewed
LBL Publications (2009)
    Cover page: High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays
    • Article
    • Peer Reviewed
    LBL Publications (2008)

    We have developed a new protocol for using Molecular Inversion Probes (MIP) to accurately and specifically measure allele copy number (ACN). The new protocol provides for significant improvements including the reduction of input DNA (from 2?g) by more than 25 fold (to 75ng total genomic DNA), higher overall precision resulting in one order of magnitude lower false positive rate, and greater dynamic range with accurate absolute copy number up to 60 copies.

      Cover page: Performance of Molecular Inversion Probes (MIP) in Allele Copy Number Determination
      • Article
      • Peer Reviewed
      UC San Francisco Previously Published Works (2007)
      We have developed a new protocol for using molecular inversion probes to accurately and specifically measure allele copy number. The new protocol provides for significant improvements, including the reduction of input DNA (from 2 mug) by more than 25-fold (to 75 ng total genomic DNA), higher overall precision resulting in one order of magnitude lower false positive rate, and greater dynamic range with accurate absolute copy number up to 60 copies.
        Cover page: Analysis of molecular inversion probe performance for allele copy number determination
        • Article
        LBL Publications (2008)
          Cover page: Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities
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