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Open Access Publications from the University of California

Scholarly Works (46 results)

  • Article
  • Peer Reviewed
National Black Law Journal, Volume 5, Issue 2 (1977)
    Cover page: Can Black Americans Play a Major Role in the Development of Africa?
    • Article
    LBL Publications (1976)
      Cover page: THE EMISSION SPECTRUM OF CURIUM
      • Article
      LBL Publications (1975)
        Cover page: A FLASH PHOTOLYSIS ESR STUDY OF PHOTOSYSTM II: SIGNAL IIvf, THE PHYSIOLOGICAL DONOR TO P680+*
        • Article
        • Peer Reviewed
        UC Davis Previously Published Works (2006)
        There has been intense interest in defining the functions of UCP2 and UCP3 during the nine years since the cloning of these UCP1 homologues. Current data suggest that both UCP2 and UCP3 proteins share some features with UCP1, such as the ability to reduce mitochondrial membrane potential, but they also have distinctly different physiological roles. Human genetic studies consistently demonstrate the effect of UCP2 alleles on type-2 diabetes. Less clear is whether UCP2 alleles influence body weight or body mass index (BMI) with many studies showing a positive effect while others do not. There is strong evidence that both UCP2 and UCP3 protect against mitochondrial oxidative damage by reducing the production of reactive oxygen species. The evidence that UCP2 protein is a negative regulator of insulin secretion by pancreatic beta-cells is also strong: increased UCP2 decreases glucose stimulated insulin secretion ultimately leading to beta-cell dysfunction. UCP2 is also neuroprotective, reducing oxidative stress in neurons. UCP3 may also transport fatty acids out of mitochondria thereby protecting the mitochondria from fatty acid anions or peroxides. Current data suggest that UCP2 plays a role in the metabolic syndrome through down-regulation of insulin secretion and development of type-2 diabetes. However, UCP2 may protect against atherosclerosis through reduction of oxidative stress and both UCP2 and UCP3 may protect against obesity. Thus, these UCP1 homologues may both contribute to and protect from the markers of the metabolic syndrome.
          Cover page: Uncoupling proteins, dietary fat and the metabolic syndrome
          • Article
          LBL Publications (1974)
            Cover page: LIGHT-INDUCED PARAMAGNETISM IN PHOTOSYNTHETIC SYSTEMS
            • Article
            LBL Publications (1988)
              Cover page: REVISIONS AND ADDITIONS TO THE ENERGY LEVELS OF NEUTRAL CURIUM, [SUP]244 CM I
              • Article
              LBL Publications (1985)
                Cover page: ENERGY LEVELS OF THE SECOND SPECTRUM OF CURIUM, Cm II
                • Thesis
                • Peer Reviewed
                UCLA Electronic Theses and Dissertations (2015)

                This dissertation studies traditional and popular music of the Wixárika (a.k.a. Huichol) people of western Mexico, focusing especially on the phenomenon of Wixárika musicians who intentionally represent themselves as indigenous “Huichol” people yet perform popular Mexican music primarily for non-indigenous audiences. This phenomenon markets ethnic identity within regional and transnational music industries, following in the footsteps of Wixárika people who have successfully inserted their arts and crafts into global markets. The process of becoming indigenous cosmopolitan capitalists is partly the result of direct assimilatory projects directed by early Mexican anthropologists and the indirect outcome of over a century of Huichol identity construction for consumption, aided greatly by foreign ethnographers and other outsiders. On one hand, the commodification of identity through handicrafts, art, and music generates income for the Wixárika people, and the resultant visibility—sometimes international in scale—may strengthen them politically as Indigenous people. Conversely, the process simultaneously supplants some of the very elements they consider central to Wixárika culture. Musicians often leave their homelands to pursue their craft, making it difficult or impossible to participate in community affairs and ceremonies, and leaving their children bereft of Wixárika language and “customs.” Such people who represent the “customs” but do not practice them are sometimes disparaged as “half disqualified” or “Huichol de pirata” (pirated Huichol), illuminating identity’s commodity form. As the first English-language study of Wixárika music, this dissertation examines the paradox of identity commodification, developing a tripartite model of identity that shows the vital (albeit sometimes inadvertent) role of ethnography in defining the essence of the commodity form of Huichol identity.

                • 2 supplemental ZIPs
                Cover page: Wixárika Music, Huichol Music: The Construction and Commodification of an Indigenous Identity
                • Article
                • Peer Reviewed
                UC Davis Previously Published Works (2009)

                Background

                Maternal genotype has lifetime effects on progeny, but few specific genes, and no proteases, are known to underlie maternal effects. Prolyl endopeptidase (PREP) is a serine protease with putative substrates that regulate appetite or milk production.

                Objective

                To test effects of PREP on obesity phenotypes in mice.

                Design

                Mice with a gene trap (GT) of PREP (PREP(gt/gt)) on the C57BL/6J (B6) background were generated. Minimal PREP protein was detected by western blot. In Experiment 1, direct effects of PREP were measured in littermate mice derived from intercrosses of heterozygotes (PREP(WT/gt)). In Experiment 2, maternal effects of PREP were measured in reciprocal crosses of heterozygous (PREP(WT/gt)) and wild-type (WT) (PREP(WT/WT)) males and females. DIETS: Mice were fed either low-fat (LF, Experiments 1 and 2) or high-fat (HF, Experiment 1) defined diets.

                Measurements

                Adiposity index (AI) was calculated from body weight (BW) and weights of four fat depots measured in 120-day-old mice. Fasting plasma glucose, insulin and leptin were measured. In vivo plasma alpha-MSH levels were measured by targeted quantitative peptidomics.

                Results

                Experiment 1-In intercross mice, there were significant diet effects, but few genotype effects. There were no genotype effects on BW or AI in males or females on either diet. Experiment 2-In contrast, reciprocal crosses of heterozygous males or females with WT B6 revealed highly significant parent of origin effects on all traits except body length. Progeny (WT and heterozygous genotypes and both sexes) born to female PREP(WT/gt) heterozygotes had fat pads that weighed as much as -twofold more at 120 days old than progeny born to male heterozygotes.

                Conclusion

                Heterozygosity for PREP GT results in highly significant maternal effects, whereas homozygosity for the PREP(gt/gt) mutation has a much more limited direct effect.
                  Cover page: Maternal influence of prolyl endopeptidase on fat mass of adult progeny
                  • Article
                  • Peer Reviewed
                  UC Davis Previously Published Works (2019)
                  Blunt cardiac injury (BCI), also referred to in the literature as a cardiac contusion, is a known cause of myocardial injury. It is often challenging to diagnose this condition in the absence of clear diagnostic criteria. Furthermore, its clinical presentation is highly variable depending on the severity, type, and duration of the trauma, as well as the timing from the initial insult. The clinical manifestation of BCI ranges from none to fatal arrhythmias to cardiac wall rupture seen on post-mortem examination. Cardiac biomarkers and electrocardiograms (EKG) are usually helpful in identifying cardiac trauma but are not necessarily abnormal in all cases. Falls by slipping on ice are common in the winter, but rarely do people present with a myocardial injury with these mechanical events. We describe the case of a cardiac contusion with an unusual presentation and an unusual cause, whereby both the initial EKG and troponin level were normal, and the patient presented with an atrioventricular (AV) block two weeks after "slipping on ice".
                    Cover page: Story of an Unfortunate Fall: Cardiac Contusion Presenting with an Atrioventricular Block
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