Who has which job? When this answer differs by race group or sex, inefficiencies such as labor market discrimination or suboptimal investment in education may be impeding productivity and sustaining inequities. We use US Census data to analyze the occupational structure of American Indian/Alaska Native (AI/AN) workers relative to non-Hispanic white workers. Relative to white workers, AI/AN workers are generally overrepresented in low-skilled occupations and underrepresented in high-skilled occupations, especially men and single-race AI/AN workers. AI/AN occupational dissimilarity does not appear to have declined substantially since 1980. Sex-specific multivariate analyses do not remove the significant inequalities in observed occupational outcomes.