Clic1, Chloride Intracellular Channel 1, is a ubiquitously expressed chloride channel protein known to be involved in various biological processes. In our previous studies, we have found that Clic1 is involved in olanzapine-induced hyperphagia and may play a role in food intake regulation. Also, it has been found that Clic1 is highly expressed in exosomes. Exosomes are small extracellular vesicles sized that are secreted from many different types of cells and act as information vehicles by transporting proteins and RNAs to the recipient cells. They can freely diffuse in all body fluids and be taken up by different organs. In recent years, it has been shown that exosomes play an important role in inter-organ crosstalk in the homeostatic control of metabolism. The objective of this thesis is to discuss the potential role of exosomal Clic1 in the regulation of metabolic processes. In addition to literature review, we performed experiments by checking if the level of Clic1 expression would be affected by diet type and food deprivation. High-fat-diet fed mice had elevated plasma-derived exosomal Clic1 levels, but this effect was not significant. Fasting resulted in an approximately 2-fold increase in exosomal Clic1, and glucose injection resulted in a trend in decreased exosomal Clic1 expression, but these effects were also not statistically significant, and further additional samples need to be studied to determine a more consistent result. Taken together, this study suggests that future studies are needed to further investigate the potential role of exosomal Clic1 as a regulator of feeding behavior and a coordinator of metabolism.