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Scholarly Works (1 results)
Article
Peer Reviewed
EGFR blockade prevents glioma escape from BRAFV
600E
targeted therapy
Weiss, William
;
Prados, Michael
;
Nicolaides, Theodore
;
Yao, TW
;
Zhang, J
;
Weiss, WA
;
David, C
UC San Francisco Previously Published Works
(2015)
Mutational activation of BRAF (BRAFV
600E
) occurs in pediatric glioma and drives aberrant MAPK signaling independently of upstream cues. Targeted monotherapy against BRAFV
600E
displays efficacy in pre-clinical models of glioma, however
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