We present a structured matrix factorization approach to analyzing calciumimaging recordings of large neuronal ensembles. Our goal is to simultaneouslyidentify the locations of the neurons, demix spatially overlapping components,and denoise and deconvolve

Synthetic photochromic compounds can be designed to control a variety of proteins and their biochemical functions in living cells, but the high spatiotemporal precision and tissue penetration of two-photon stimulation have never been investigated in these