Ethylene glycol (EG) starts to attract attention as a robust solvent for lignin processing. However its solution structure has not been revealed. In this effort, small angle neutron scattering (SANS) and dynamic light scattering are used to understand the dissolution of kraft lignin in EG and the impact of the resultant solution structure on nanoparticle preparation. Lignin solutions with different concentrations (0.6 to 13.0 wt%) were explored by SANS, allowing evaluation of the solvent quality, the conformation of lignin subunits and their aggregation in EG. Molecular interactions between EG and lignin were discussed and compared to those between DMSO and lignin. The process of nanoparticle preparation from EG solutions upon addition of anti-solvents was also discussed.

As the most abundant source of renewable aromatic compounds on the planet, lignin is gaining growing interest in replacing petroleum-based chemicals and products. Value-added applications of lignin are also essential for the economic viability of future bio-refineries. It is however an under-utilized natural resource due to its structural heterogeneities. Lignin nanoparticles offer many opportunities for value-added applications of lignin. The solution structures of lignin were proposed as one of the key elements in controlling lignin nano-/micro-particle preparation. Fundamental understanding of solution structures of lignin aid in designing and better fabrication of lignin nanoparticles. A deeper understanding of the observed experimental results also points to the need for detailed studies of lignin in solution. This review consists of two major topics, the solution structures of lignin and lignin nano-/micro-particle preparation. Suggestions for future studies regarding these two topics were also put forward.