Background: Childhood cancer survivors (CCSs) face long-term health challenges, yet the health and specific needs of LatinAmerican survivors remain underexplored. This study aimed to describe the health-related, psychosocial late effects, andinformation needs among CCSs in the region.Methods: This mixed-method study combined quantitative data from an online survey with qualitative insights from follow-upinterviews, involving CCSs from the largest regional survivor network and additional participants recruited through snowballsampling. We report the quantitative results here. The survey was adapted from the Childhood Cancer Survivor Study SurveyFollow-Up and the Needs Assessment Questionnaire (CCSS-NAQ).Results: A total of 135 CCSs from 16 Latin American countries participated (mean age 26.1 years). The most frequent late effectswere mental health (61.2%), endocrine (58.6%), and cardiovascular (42.1%). Infertility was prevalent (16.9%), with nearly one-thirdunsure of their fertility status. Anxiety (51.1%) and depression (31.8%) were common. Significant findings included higher ratesof endocrine disorders in females (p = 0.0018) and those who had received radiation (p = 0.048), respiratory problems in stemcell transplantation recipients (p = 0.026), and auditory impairment in survivors of a solid tumor (p = 0.0031). While most feltinformed about their health, only one-third had regular medical follow-up and access to psychological care. Survivors expresseda strong interest in learning more about fertility and mental health, with a preference for digital information