This review has provided an update on current progress in identifying recurring sites of chromosome change in human malignant melanoma. Despite methodologic difficulties, a recurring and decidedly nonrandom pattern of chromosome change is beginning to emerge for this neoplasia. It appears most reasonable to suggest that as an increasing number of cases of melanoma are cytogenetically examined, the stratification of patients into defined subgroups based upon specific chromosome abnormalities will be possible. At present, the clinical utility of chromosome analysis in malignant melanoma is indeterminate. However, the pinpointing of regions of the genome which are characteristically altered in this tumor may be of significant benefit in targeting future molecular (and hopefully mechanistic) investigations. Continued study of the basic genetics of malignant melanoma would appear a particularly fruitful avenue to continue and it assuredly will add to our understanding of the causation, progression, and ultimately the control of this disorder.