Sirtuins in neurodegenerative diseases: An update on potential mechanisms
- Author(s): Min, SW
- Sohn, PD
- Cho, SH
- Swanson, RA
- Gan, L
- et al.
Published Web Locationhttps://doi.org/10.3389/fnagi.2013.00053
Silent information regulator 2 proteins (sirtuins or SIRTs) are a group of deacetylases (or deacylases) whose activities are dependent on and regulated by nicotinamide adenine dinucleotide (NAD+). Compelling evidence supports that sirtuins play major roles in many aspects of physiology, especially in pathways related to aging - the predominant and unifying risk factor for neurodegenerative diseases. In this review, we highlight the molecular mechanisms underlying the protective effects of sirtuins in neurodegenerative diseases, focusing on protein homeostasis, neural plasticity, mitochondrial function, and sustained chronic inflammation. We will also examine the potential and challenges of targeting sirtuin pathways to block these pathogenic pathways. © 2013 Min, Sohn, Cho, Swanson and Gan.
Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.