Skip to main content
eScholarship
Open Access Publications from the University of California

Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians

  • Author(s): Chen, P
  • Takeuchi, F
  • Lee, JY
  • Li, H
  • Wu, JY
  • Liang, J
  • Long, J
  • Tabara, Y
  • Goodarzi, MO
  • Pereira, MA
  • Kim, YJ
  • Go, MJ
  • Stram, DO
  • Vithana, E
  • Khor, CC
  • Liu, J
  • Liao, J
  • Ye, X
  • Wang, Y
  • Lu, L
  • Young, TL
  • Lee, J
  • Thai, AC
  • Cheng, CY
  • Van Dam, RM
  • Friedlander, Y
  • Heng, CK
  • Koh, WP
  • Chen, CH
  • Chang, LC
  • Pan, WH
  • Qi, B
  • Isono, M
  • Zheng, W
  • Cai, Q
  • Gao, Y
  • Yamamoto, K
  • Ohnaka, K
  • Takayanagi, R
  • Kita, Y
  • Ueshima, H
  • Hsiung, CA
  • Cui, J
  • Sheu, WHH
  • Rotter, JI
  • Chen, YDI
  • Hsu, C
  • Okada, Y
  • Kubo, M
  • Takahashi, A
  • Tanaka, T
  • Van Rooij, FJA
  • Ganesh, SK
  • Huang, J
  • Huang, T
  • Yuan, J
  • Hwang, JY
  • Gross, MD
  • Assimes, TL
  • Miki, T
  • Shu, XO
  • Qi, L
  • Chen, YT
  • Lin, X
  • Aung, T
  • Wong, TY
  • Teo, YY
  • Kim, BJ
  • Kato, N
  • Tai, ES
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284402/
No data is associated with this publication.
Abstract

Glycated hemoglobin A1c(HbA1c) is used as a measure of glycemic control and also as a diagnostic criterion for diabetes. To discover novel loci harboring common variants associated with HbA1cin East Asians, we conducted a meta-analysis of 13 genome-wide association studies (GWAS; N = 21,026). We replicated our findings in three additional studies comprising 11,576 individuals of East Asian ancestry. Ten variants showed associations that reached genome-wide significance in the discovery data set, of which nine (four novel variants at TMEM79 [ P value = 1.3 × 10-23], HBS1L/MYB [8.5 × 10-15], MYO9B [9.0 × 10-12], and CYBA [1.1 × 10-8] as well as five variants at loci that had been previously identified [CDKAL1, G6PC2/ ABCB11, GCK, ANK1, and FN3KI]) showed consistent evidence of association in replication data sets. These variants explained 1.76% of the variance in HbA1c. Several of these variants (TMEM79, HBS1L/MYB, CYBA, MYO9B, ANK1, and FN3K) showed no association with either blood glucose or type 2 diabetes. Among individuals with nondiabetic levels of fasting glucose (<7.0 mmol/L) but elevated HbA1c(≥6.5%), 36.1% had HbA1c<6.5% after adjustment for these six variants. Our East Asian GWAS meta-analysis has identified novel variants associated with HbA1cas well as demonstrated that the effects of known variants are largely transferable across ethnic groups. Variants affecting erythrocyte parameters rather than glucose metabolism may be relevant to the use of HbA1cfor diagnosing diabetes in these populations. © 2014 by the American Diabetes Association.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item