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Inhibitors of the Influenza A Virus M2 Proton Channel Discovered Using a High-Throughput Yeast Growth Restoration Assay

  • Author(s): Degrado, William
  • Balgi, AD
  • Wang, J
  • Cheng, DYH
  • Ma, C
  • Pfeifer, TA
  • Shimizu, Y
  • Anderson, HJ
  • Pinto, LH
  • Lamb, RA
  • DeGrado, WF
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3562233?pdf=render
No data is associated with this publication.
Abstract

The M2 proton channel of the influenza A virus is the target of the anti-influenza drugs amantadine and rimantadine. The effectiveness of these drugs has been dramatically limited by the rapid spread of drug resistant mutations, mainly at sites S31N, V27A

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