Molecular mechanisms of hypoxic responses via unique roles of Ras1, Cdc24 and Ptp3 in a human fungal pathogen Cryptococcus neoformans.
- Author(s): Walter, Peter
- Chang, YC
- Khanal, A
- Garraffo, HM
- Walter, PJ
- Leerkes, M
- Kwon-Chung, KJ
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3998916?pdf=render
Cryptococcus neoformans encounters a low oxygen environment when it enters the human host. Here, we show that the conserved Ras1 (a small GTPase) and Cdc24 (the guanine nucleotide exchange factor for Cdc42) play an essential role in cryptococcal growth in
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