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Immunofluorescence assay for serologic diagnosis of SARS.

  • Author(s): Chan, Paul KS
  • Ng, King-Cheung
  • Chan, Rickjason CW
  • Lam, Rebecca KY
  • Chow, Viola CY
  • Hui, Mamie
  • Wu, Alan
  • Lee, Nelson
  • Yap, Florence HY
  • Cheng, Frankie WT
  • Sung, Joseph JY
  • Tam, John S
  • et al.
Abstract

We evaluated an indirect immunofluorescence assay based on virus-infected cells for detecting anti-severe acute respiratory syndrome-associated coronavirus (SARS-CoV) immunoglobulin (Ig) G antibody. All confirmed SARS cases demonstrated seroconversion or fourfold rise in IgG antibody titer; no control was positive. Sensitivity and specificity of this assay were both 100%. Immunofluorescence assay can ascertain the status of SARS-CoV infection.

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