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A photoCORM nanocarrier for CO release using NIR light.

  • Author(s): Pierri, Agustin E;
  • Huang, Po-Ju;
  • Garcia, John V;
  • Stanfill, James G;
  • Chui, Megan;
  • Wu, Guang;
  • Zheng, Nanfeng;
  • Ford, Peter C
  • et al.
Abstract

A water-soluble nanocarrier for a photo-activated CO releasing moiety (photoCORM) that can be triggered with NIR excitation is described. This has an upconversion nanoparticle core encapsulated by an amphiphilic polymer imparting both water solubility and a hydrophobic interior containing the photoCORM trans-Mn(bpy)(PPh3)2(CO)2. Such an ensemble offers a unique strategy for CO delivery to biological targets.

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