Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells.
- Author(s): Ronen, Sabrina
- Viswanath, P
- Chaumeil, MM
- Ronen, SM
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4789800?pdf=render
Mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) have recently been identified as drivers in the development of several tumor types. Most notably, cytosolic IDH1 is mutated in 70-90% of low-grade gliomas and upgraded glioblastomas, and mito