GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery.
- Author(s): Wexselblatt, Ezequiel
- Esko, Jeffrey D
- Tor, Yitzhak
- et al.
Published Web Locationhttps://doi.org/10.1021/nn507382n
GNeosomes, lysosomotropic lipid vesicles decorated with guanidinoneomycin, can encapsulate and facilitate the cellular internalization and lysosomal delivery of cargo ranging from small molecules to high molecular weight proteins, in a process that is exclusively dependent on cell surface glycosaminoglycans. Their cellular uptake mechanism and co-localization with lysosomes, as well as the delivery, release, and activity of internalized cargo, are quantified. GNeosomes are proposed as a universal platform for lysosomal delivery with potential as a basic research tool and a therapeutic vehicle.