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GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery.

  • Author(s): Wexselblatt, Ezequiel
  • Esko, Jeffrey D
  • Tor, Yitzhak
  • et al.

Published Web Location

https://doi.org/10.1021/nn507382n
No data is associated with this publication.
Abstract

GNeosomes, lysosomotropic lipid vesicles decorated with guanidinoneomycin, can encapsulate and facilitate the cellular internalization and lysosomal delivery of cargo ranging from small molecules to high molecular weight proteins, in a process that is exclusively dependent on cell surface glycosaminoglycans. Their cellular uptake mechanism and co-localization with lysosomes, as well as the delivery, release, and activity of internalized cargo, are quantified. GNeosomes are proposed as a universal platform for lysosomal delivery with potential as a basic research tool and a therapeutic vehicle.

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Main Content

This item is under embargo until December 31, 2999.