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Early Release - Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab - Volume 27, Number 1—January 2021 - Emerging Infectious Diseases journal - CDC
- Solomon, Isaac H;
- Ganesh, Vijay S;
- Yu, Guixia;
- Deng, Xian Ding;
- Wilson, Michael R;
- Miller, Steve;
- Milligan, Tracey A;
- Mukerji, Shibani S;
- Mathewson, Abigail;
- Linxweiler, Justin;
- Morse, Darlene;
- Ritter, Jana M;
- Staples, J Erin;
- Hughes, Holly;
- Gould, Carolyn V;
- Sabeti, Pardis C;
- Chiu, Charles Y;
- Piantadosi, Anne
- et al.
Published Web Location
https://doi.org/10.3201/eid2701.203448Abstract
A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterization of viral genomes from the cerebrospinal fluid, cerebellum, and cerebral cortex.
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