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Optical Doppler tomography for noninvasive imaging of in-vivo blood flow

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We report the development of an optical technique for noninvasive in vivo imaging of tissue structure and blood flow dynamics with high spatial resolution (2 - 15 micrometer) in biological systems. The technique is based on coherence optical Doppler tomography (ODT), which combines Doppler velocimetry with optical coherence tomography to measure blood flow velocity at discrete spatial locations. The exceptionally high resolution of ODT allows noninvasive in vivo imaging of both blood microcirculation and tissue structures surrounding the vessel, which has significance for biomedical research and clinical applications. Tomographic velocity imaging of in vivo blood flow in a rat mesentery is demonstrated. ©2004 Copyright SPIE - The International Society for Optical Engineering.

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