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Exploiting the promiscuity of imatinib

  • Author(s): Lee, SJ
  • Wang, JYJ
  • et al.

Published Web Location

https://doi.org/10.1186/jbiol134
Abstract

The protein kinase inhibitor imatinib, also known as Gleevec, has been a notable success in treating chronic myelogenous leukemia. A recent paper in BMC Structural Biology reports a 1.75 Å crystal structure of imatinib bound to the oxidoreductase NQO2 and reveals insights into the binding specificity and the off-target effects of the inhibitor. © 2009 BioMed Central Ltd.

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