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Open Access Publications from the University of California

Exploiting the promiscuity of imatinib.

  • Author(s): Lee, Shun J
  • Wang, Jean YJ
  • et al.

Published Web Location

https://doi.org/10.1186/jbiol134
Abstract

The protein kinase inhibitor imatinib, also known as Gleevec, has been a notable success in treating chronic myelogenous leukemia. A recent paper in BMC Structural Biology reports a 1.75 A crystal structure of imatinib bound to the oxidoreductase NQO2 and reveals insights into the binding specificity and the off-target effects of the inhibitor.

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