Skip to main content
Open Access Publications from the University of California


UC San Francisco Previously Published Works bannerUCSF

Tracing diagnosis trajectories over millions of patients reveal an unexpected risk in schizophrenia.

  • Author(s): Paik, Hyojung;
  • Kan, Matthew J;
  • Rappoport, Nadav;
  • Hadley, Dexter;
  • Sirota, Marina;
  • Chen, Bin;
  • Manber, Udi;
  • Cho, Seong Beom;
  • Butte, Atul J
  • et al.

The identification of novel disease associations using big-data for patient care has had limited success. In this study, we created a longitudinal disease network of traced readmissions (disease trajectories), merging data from over 10.4 million inpatients through the Healthcare Cost and Utilization Project, which allowed the representation of disease progression mapping over 300 diseases. From these disease trajectories, we discovered an interesting association between schizophrenia and rhabdomyolysis, a rare muscle disease (incidence < 1E-04) (relative risk, 2.21 [1.80-2.71, confidence interval = 0.95], P-value 9.54E-15). We validated this association by using independent electronic medical records from over 830,000 patients at the University of California, San Francisco (UCSF) medical center. A case review of 29 rhabdomyolysis incidents in schizophrenia patients at UCSF demonstrated that 62% are idiopathic, without the use of any drug known to lead to this adverse event, suggesting a warning to physicians to watch for this unexpected risk of schizophrenia. Large-scale analysis of disease trajectories can help physicians understand potential sequential events in their patients.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View