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WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma.

  • Author(s): Liau, Linda
  • Weiss, William
  • Zhukova, N
  • Ramaswamy, V
  • Remke, M
  • Martin, DC
  • Castelo-Branco, P
  • Zhang, CH
  • Fraser, M
  • Tse, K
  • Poon, R
  • Shih, DJH
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4297452?pdf=render
No data is associated with this publication.
Abstract

TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance and can be used to sensitize TP

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