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Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate.

  • Author(s): Crowell, Preston D;
  • Fox, Jonathan J;
  • Hashimoto, Takao;
  • Diaz, Johnny A;
  • Navarro, Héctor I;
  • Henry, Gervaise H;
  • Feldmar, Blake A;
  • Lowe, Matthew G;
  • Garcia, Alejandro J;
  • Wu, Ye E;
  • Sajed, Dipti P;
  • Strand, Douglas W;
  • Goldstein, Andrew S
  • et al.
Abstract

Aging is associated with loss of tissue mass and a decline in adult stem cell function in many tissues. In contrast, aging in the prostate is associated with growth-related diseases including benign prostatic hyperplasia (BPH). Surprisingly, the effects of aging on prostate epithelial cells have not been established. Here we find that organoid-forming progenitor activity of mouse prostate basal and luminal cells is maintained with age. This is caused by an age-related expansion of progenitor-like luminal cells that share features with human prostate luminal progenitor cells. The increase in luminal progenitor cells may contribute to greater risk for growth-related disease in the aging prostate. Importantly, we demonstrate expansion of human luminal progenitor cells in BPH. In summary, we define a Trop2+ luminal progenitor subset and identify an age-related shift in the luminal compartment of the mouse and human prostate epithelium.

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