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Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations

  • Author(s): Dill, Ken;
  • Kortkhonjia, E;
  • Brandman, R;
  • Zhou, JZ;
  • Voelz, VA;
  • Chorny, I;
  • Kabakoff, B;
  • Patapoff, TW;
  • Dill, KA;
  • Swartz, TE
  • et al.

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The solution dynamics of antibodies are critical to antibody function. We explore the internal solution dynamics of antibody molecules through the combination of time-resolved fluorescence anisotropy experiments on IgG1 with more than two microseconds of a

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