Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes
- Author(s): Verkman, Alan
- Smith, AJ
- Jin, BJ
- Ratelade, J
- Verkman, AS
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3926963?pdf=render
The astrocyte water channel aquaporin-4 (AQP4) is expressed as heterotetramers of M1 and M23 isoforms in which the presence of M23-AQP4 promotes formation of large macromolecular aggregates termed orthogonal arrays. Here, we demonstrate that the AQP4 aggre
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