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Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes

  • Author(s): Verkman, Alan;
  • Smith, AJ;
  • Jin, BJ;
  • Ratelade, J;
  • Verkman, AS
  • et al.

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The astrocyte water channel aquaporin-4 (AQP4) is expressed as heterotetramers of M1 and M23 isoforms in which the presence of M23-AQP4 promotes formation of large macromolecular aggregates termed orthogonal arrays. Here, we demonstrate that the AQP4 aggre

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