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Open Access Publications from the University of California

A diagnostically challenging case of CD8+ primary cutaneous gamma/delta T-cell lymphoma

  • Author(s): Pitch, Michelle A
  • Kim, Kevin H
  • Manning, Trey
  • Smoller, Bruce R
  • Wong, Henry K
  • Kaley, Jennifer R
  • et al.
Creative Commons 'BY-NC-ND' version 4.0 license

Primary cutaneous gamma/delta T-cell lymphoma (PCγδTCL) is a rare form of cutaneous lymphoma characterized by abnormal clonal proliferation of mature, activated gamma-delta T cells expressing the γδ heterodimer of the T-cell receptor (TCR). As an entity, PCγδTCL has recently undergone diagnostic revision since its introduction in the 2008 WHO classification of cutaneous lymphomas and confirmedin 2016. Nonetheless, diagnosis remains difficult both clinically and histologically, given its broad range of clinical manifestations and immunohistochemical phenotypes. Herein, we present a rare case of CD8+ PCγδTCL with a discussion highlighting theheterogeneity within this entity.

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