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Chemical Genetics Reveals a Specific Requirement for Cdk2 Activity in the DNA Damage Response and Identifies Nbs1 as a Cdk2 Substrate in Human Cells

  • Author(s): Shokat, Kevan;
  • Wohlbold, L;
  • Merrick, KA;
  • De, S;
  • Amat, R;
  • Kim, JH;
  • Larochelle, S;
  • Allen, JJ;
  • Zhang, C;
  • Shokat, KM;
  • Petrini, JHJ
  • et al.

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The cyclin-dependent kinases (CDKs) that promote cell-cycle progression are targets for negative regulation by signals from damaged or unreplicated DNA, but also play active roles in response to DNA lesions. The requirement for activity in the face of DNA

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