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Open Access Publications from the University of California

Estimation of malaria haplotype and genotype frequencies: A statistical approach to overcome the challenge associated with multiclonal infections

  • Author(s): Rosenthal, Philip
  • Taylor, AR
  • Flegg, JA
  • Nsobya, SL
  • Yeka, A
  • Kamya, MR
  • Rosenthal, PJ
  • Dorsey, G
  • Sibley, CH
  • Guerin, PJ
  • Holmes, CC
  • et al.

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Background: Reliable measures of anti-malarial resistance are crucial for malaria control. Resistance is typically a complex trait: multiple mutations in a single parasite (a haplotype or genotype) are necessary for elaboration of the resistant phenotype.

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